TUDCA, short for tauroursodeoxycholic acid, has quietly become one of the most clinically supported ingredients for liver repair, bile support, and cellular protection. Once reserved for prescription use in Asia and Europe, this bile acid derivative is now available in purified supplement form, offering measurable benefits for liver enzyme normalization, mitochondrial stability, and endoplasmic reticulum stress reduction.
If you’re looking for the best TUDCA supplement, this guide reviews clinically validated brands, dosage data, and quality markers that separate verified formulas from under-dosed capsules.
What Is TUDCA and Why It Matters
TUDCA is a water-soluble bile acid that plays a key role in how the liver processes fats, detoxifies hormones, and regulates bile flow. Unlike general liver cleanses or herbal blends, TUDCA has peer-reviewed research behind it — including studies on non-alcoholic fatty liver disease (NAFLD), cholestasis, and drug-induced liver injury.
Clinical evidence shows that TUDCA helps:
- Support bile flow and prevent bile acid toxicity
- Reduce ALT and AST enzyme levels associated with liver stress
- Improve insulin sensitivity through better lipid metabolism
- Protect mitochondria from oxidative stress and inflammation
- Reduce ER stress, which is linked to apoptosis in liver cells
In simpler terms, TUDCA helps your liver process toxins more efficiently, protects cells from degeneration, and may even support brain and gut health through the bile-acid signaling network.
What to Look for in a High-Quality TUDCA Supplement
Because TUDCA’s popularity has exploded, many products now flood the market — often with low purity or mislabeled potency. A trustworthy supplement should include:
- High purity (>95%) pharmaceutical-grade TUDCA
- Third-party testing or NSF certification for contaminants and dosage accuracy
- Transparent labeling showing mg per capsule and FU equivalence (if combined with bile-acid complexes)
- No fillers such as magnesium stearate, soy, or artificial colorants
- Capsule strength disclosure — typically 250 mg or 500 mg per serving
Avoid proprietary blends or “liver detox” stacks that hide ingredient amounts. For therapeutic use, 250–500 mg once or twice daily is the most commonly studied dosage range.
Clinically Reviewed TUDCA Brands (2025 Edition)
Below are the most trusted TUDCA supplements available today — chosen for their purity, clinical transparency, and consistent customer validation.
| Brand | Strength | Certifications | Highlights |
|---|---|---|---|
| Double Wood Supplements TUDCA | 500 mg per capsule | Third-party tested, Made in USA | High-purity TUDCA, independent lab-verified, excellent cost per gram |
| Nutricost TUDCA | 250 mg per capsule | GMP, Non-GMO | Trusted budget option with solid purity score and transparent sourcing |
| Nootropics Depot TUDCA | 250 mg per capsule | Independent HPLC testing | Clinical-grade quality, detailed COA, ideal for stacking with NAC or choline |
| Revive MD TUDCA | 250 mg per capsule | NSF Certified Facility | Practitioner-grade liver formula designed for athletes and high-performance users |
| Thorne TUDCA (Clinical Formulation) | 250 mg per capsule | NSF Certified for Sport® | Medical-grade bile acid complex, recommended by integrative practitioners |
Each of these brands uses direct-sourced tauroursodeoxycholic acid, tested for purity and heavy metals. Differences mainly come down to dosage per capsule, certification, and price per gram — key metrics for discerning buyers.
Recommended Dosage and Stacking Strategy
Most human studies use 500 mg per day, divided into two 250 mg doses with meals.
Some clinical protocols double that (1,000 mg) for short-term liver repair cycles, but long-term maintenance typically stays at 250–500 mg daily.
Stacking strategies for advanced users:
- TUDCA + NAC (N-acetyl cysteine): synergistic antioxidant effect for liver enzymes.
- TUDCA + Milk Thistle (Silymarin): enhances hepatocyte regeneration.
- TUDCA + Omega-3s: supports bile fluidity and lipid metabolism.
Avoid combining with prescription bile acid medications (e.g., ursodiol) unless advised by a physician.
Safety, Side Effects, and Precautions
TUDCA is considered well-tolerated in clinical doses. Reported mild effects include digestive upset or loose stool if taken on an empty stomach.
Caution is warranted for:
- Those on blood-pressure or cholesterol medications
- Pregnant or breastfeeding individuals (insufficient data)
- People with active gallbladder obstruction or bile duct disease
Always confirm with a healthcare professional before long-term use or stacking with prescription agents.
If your goal is to support liver repair, improve bile flow, and protect cellular function, TUDCA is one of the few natural compounds backed by measurable clinical results.
When selecting a supplement, purity and testing matter more than marketing claims.
- Best overall: Double Wood Supplements TUDCA — highest purity, lab-verified.
- Best clinical option: Thorne TUDCA — NSF-certified, practitioner grade.
- Best value: Nutricost TUDCA — affordable, reliable for long-term support.
Commit to a consistent regimen, stay hydrated, and pair TUDCA with balanced nutrition and regular liver enzyme monitoring for optimal outcomes.
