A team of British researchers managed to reach a new landmark as they decoded a DNA sequence that is 10.000 longer than normal ones and double in length when compared to the previous record holder.
The research took place as part of an informal competition where participant have to unravel the complete sequence of a chromosome in one sitting. The project focused on correctly decrypting the DNA and also marked a new technological advancement.
It is hoped that the results will improve the process of genetic sequencing since up to this point DNA has to be split into smaller segments that are sequenced and linked again after the sequencing process is finished.
Using the right tools
The technology used for DNA sequencing has improved considerably in the last decade. The costly human genome project would be considerably more affordable if it was started today, as the prices dropped from billions to thousands of dollars. As the technology continues to evolve personal DNA sequencing will soon become available. Controversies are already brewing as parents could find out the genetic structure of their child before he is born.
The main puzzle is the correct reassembling of analyzed DNA sequences. Nanopore sequencing promises to increase the speed of analysis while maintain accuracy, as divisions will be no longer needed even when it comes to very complicated genomes.
The method will also allow researchers to improve our knowledge about the human body, the spread of pathogens in select areas and other valuable information.
One of the most valuable applications will lead to a better understanding of cancer as mutated chromosomes rearrange themselves wrongly. The team is currently focusing on cancer cells, as the puzzle-like structure poses an additional challenge from researchers. When asked about the estimated reign of the current record the researchers confidently answered that it will hold for at least a year.
It remains to be seen what they will be able to find in the following years.