It has been revealed that the Pfizer vaccine is making aberrant proteins in the body. Check out more details about the autoimmunity events below.
Pfizer vaccine in the news again
A recent study conducted by researchers from Cambridge has found that there’s a possibility of around 1 in 10 that Pfizer’s mRNA COVID-19 vaccines may not generate spike proteins but instead produce something else. This has raised concerns among experts about an autoimmune response.
The study has also discovered that 8% of the time, the Pfizer mRNA COVID-19 vaccines are mistranslated, leading to the creation of unintended proteins.
This mistranslation is primarily caused by Pfizer’s modification to their mRNA bases.
“Our work presents both a concern and a solution for this new type of medicine,” said leading author Anne Willis in the study’s press release.
mRNA vaccines can be thought of as a set of instructions that are used to make spike proteins. Once the vaccine enters the cell, ribosomes interpret the mRNA instructions to make proteins, such as spike proteins.
However, errors in the final protein may occur if the instructions are misinterpreted.
These errors can range from minor, like misspelling a word in a text, to more harmful ones.
This misinterpretation is called a frameshift, which happens when one or two mRNA bases are skipped. mRNA bases are translated in sets of threes, so skipping a base can affect all the sequences downstream, leading to the formation of new proteins.
“Frameshifting results in the production multiple, unique and potentially aberrant proteins,” immunologist Jessica Rose wrote in her Substack article discussing the study.
The Pfizer mRNA vaccines use N1-methylpseudouridine, which is not commonly found in natural mRNA. This makes the mRNA sequence stronger and less likely to be broken down by the immune system.
Therefore, some scientists refer to the mRNA vaccines as modified RNA, or modRNA.
The researchers were able to reduce the creation of frameshifted proteins by making additional edits to the mRNA sequences.
Although “there is no evidence: that the aberrant proteins generated by Pfizer vaccination are associated with adverse outcomes, for future use of mRNA technology, it is important that “mRNA sequence design is modified” to reduce these shifts, the authors concluded.
