New SARS-CoV-2-Related Mutant Induces Deadly Brain Infection, In Humanized Mice Study

New SARS-CoV-2-Related Mutant Induces Deadly Brain Infection, In Humanized Mice Study

Scientists are continuing to conduct research with dual-use potential on viruses, despite the warning against risky biological experiments sent by the COVID-19 pandemic.

New study reveals more shocking data Sars-CoV-2

Recently, a team of Chinese researchers linked to the Chinese military published a study revealing that a newly discovered variant of the pangolin coronavirus causes a 100% fatality rate in humanized mice due to severe brain infection.

The study was conducted by researchers from the Beijing Advanced Innovation Center for Soft Matter Science and Engineering and the Research Center for Clinical Medicine of the Fifth Medical Center of PLA General Hospital.

They created a variant of the SARS-CoV-2-related pangolin coronavirus known as GX_P2V(short_3UTR), which has killed all human ACE2-transgenic mice exposed to it. The findings suggest that there is a potential risk of spillover into humans.

The abstract reads:

“SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.”

The study, led by Lai Wei, Shuiqing Liu, Shanshan Lu, et al., involved cloning the GX_P2V(short_3UTR) mutant to assess its pathogenicity in 23 human ACE2 mice, according to the notes.

It’s alarming that the mutant virus caused 100% mortality in infected mice within 7-8 days, due to high viral loads in both lung and brain tissues.

According to the study,

“The mice began to exhibit a decrease in body weight starting from day 5 post-infection, reaching a 10% decrease from the initial weight by day 6. By the seventh day following infection, the mice displayed symptoms such as piloerection, hunched posture, and sluggish movements, and their eyes turned white.”

The scientists have found “significant” amounts of viral RNA in various organs of the mice such as the brain, lung, turbinate, eye, and trachea.

The viral load in the lungs reached its peak on day 3 post-infection, but decreased by day 6. Meanwhile, the viral load in the brain reached its highest and deadliest level by day 6.

This indicates that severe brain infection during the later stages of infection may be the primary cause of death in these mice.

According to the clinical profile of the infected mice,

“On day 3 post-infection, shrunken neurons [essential brain cells] were visible in the cerebral cortex of the mice. By day 6, in addition to the shrunken neurons, there was focal lymphocytic infiltration around the blood vessels, although no conspicuous inflammatory reaction was observed.”

Check out the original article in order to learn more details about this.

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