According to the latest reports, it seems that frequent COVID boosters could be causing more harm compared to benefits in people with compromised immunity. Check out the latest reports about this below.
COVID boosters new reports are out
A review published in Clinical and Experimental Medicine on Jan. 27 suggests that frequent administration of mRNA COVID-19 boosters in immune-compromised individuals may hamper the immune system response.
This raises concerns about the safety and effectiveness of giving multiple vaccine doses, as it may increase the likelihood of SARS-CoV-2 infection and other pathologies.
The review also highlights that receiving multiple doses may lead to much higher levels of IgG4 antibodies and impair the activation of white blood cells, which play a crucial role in protecting the body from infections and cancer.
Immunoglobulins, also known as antibodies, are proteins produced by specialized white blood cells called B cells. While IgG4 antibodies can provide protection up to a certain level, there is increasing evidence that high levels resulting from repeated vaccinations can lead to IgG4-related diseases. These diseases involve inflammation of multiple organs, autoimmune disorders, rapid onset cancers, and autoimmune myocarditis.
Although booster doses have been recommended to enhance and prolong immunity, especially with the emergence of new variants, there is no solid proof of their effectiveness.
Moreover, the adverse effects have been ignored, according to scientist Alberto Boretti, the author of a paper on the subject.
To determine whether mRNA vaccine boosters have a negative impact on the immune response of immunocompromised individuals, Mr. Boretti conducted a literature review using the Google Scholar database.
The researcher discovered that there are very few long-term studies that assess the safety and effectiveness of administering repeated booster vaccinations to individuals with compromised immune systems, especially with a constantly evolving virus. Instead, the researcher found that administering multiple mRNA vaccine boosters can hinder the activation of CD4+ and CD8+ T cells.
These cells constitute the majority of T cells that safeguard the body by eliminating harmful pathogens and assisting in responding to infections, allergens, and tumors. CD4+ T cells are particularly crucial, as they activate other immune cells, coordinate the immune response against infections, and assist B cells in creating antibodies.
When the CD4+ T cells are impaired, it can lead to a decrease in antibody production. This can make it difficult for the body to fight against pathogens and make it more susceptible to opportunistic infections.
These infections are caused by pathogens that do not typically cause disease in individuals with healthy immune systems.
On the other hand, CD8+ T cells play a crucial role in cell-mediated immunity. They recognize and eliminate infected or abnormal cells and also help to prevent excessive inflammation. If the activation of CD8+ T cells is impaired, it can allow infections or tumor growth to persist.
“The author found mRNA COVID-19 vaccines may result in much higher levels of IgG4 antibodies, or impaired activation of CD4 + and CD8 + T cells—and that the harm of repeated vaccination may outweigh the benefit. Yet, in the U.S., the immune-compromised are the first group to receive additional vaccine doses,” Dr. Craig Wax, a physician and health care policy expert said.
